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Blood flow through the cuffed renal artery is reduced to the same extent in both WT and Smad3 KO mice. Repeated measurements of renal arterial blood flow were obtained by pulse-wave Doppler ultrasonography preoperatively and 3 days, 2 wk, and 4 wk following 2 kidney, 1 clip (2K1C) surgery. Values are means ± SE of ≥5 mice/group. *P < 0.05 vs. WT time 0. †P < 0.05 vs. KO time 0.
