Fig. 8.

Mobilization of papillary LRC after transient ischemic injury is prevented by blockade of Cxcr4. A: relative abundance of papillary LRC present in the 2 kidneys (control and ischemia) from rats 3 wk after they underwent transient ischemic injury in the left kidney (black bars). In the group of rats that received only vehicle, the number of LRC in the papilla of the kidney subjected to injury was markedly lower that in the contralateral control kidney (n = 6; P < 0.01). However, in the group of rats that received the Cxcr4 blocker AMD3100, both papillae had a similar abundance of LRC. B: representative sections of papilla from a rat receiving vehicle only; note the absence of BrdU-positive cells (i.e., LRC) in the papilla of the kidney subjected to ischemia. In contrast, the 2 papillae of a rat receiving AMD3100 had similar numbers of BrdU-positive cells. Dolicos biflorus (rhodamine) labels collecting ducts.