TABLE 1.
Demographic, virological and histopathological features of chronic hepatitis C (HCV) patients with or without insulin resistance (IR)
| IR chronic HCV Group 1 (n=48) | Non-IR HCV Group 2 (n=92) | P | |
|---|---|---|---|
| Age, years | 42±3.1 | 32.333±6.658 | 0.084 |
| Male sex, n/n (%) | 21/48 (43.75) | 54/92 (58.69) | 0.039* |
| BMI, kg/m2 | 27.889±1.571 | 21.01±2.646 | 0.001* |
| ALT, IU/L | 167±106.864 | 99.80±64.794 | 0.264 |
| AST, IU/L | 146.800±75.191 | 130.000±97.747 | 0.768 |
| Fasting glucose, mmol/L | 5.20±0.39 | 5.22±0.29 | 0.866 |
| Fasting insulin, pmol/L | 105.6±1.15 | 43.2±11.4 | 0.001* |
| Viral load, log10 copies/mL | 6.34±0.54 | 5.50±0.90 | 0.022 * |
| Grade of inflammation ≥3, n/n (%) | 16/48 (33.33) | 23/92 (25.1) | 0.415 |
| Fibrosis F≥3, n/n (%) | 23/48 (47.91) | 22/92 (23.91) | 0.007* |
| Steatosis >5%, n/n (%) | 35/48 (72.9) | 27/92 (29.34) | 0.0001* |
Data presented as mean ± SD unless otherwise indicated.
*
Statistically significant (P<0.05). ALT Alanine aminotransferase; AST Asparatate aminotransferase; BMI Body mass index