TABLE 1.

Evaluated treatments for nonalcoholic fatty liver disease

Lifestyle intervention

Calorie restriction

Exercise

Pharmacological therapy

Insulin sensitizers: metformin, thiazolidinediones, incretin-based therapies

Lipid-lowering agents: statins, fibrates, PUFA

Cytoprotective and antioxidant agents: URSO, Vitamin E, silymarin, betaine

Anti-TNF-α agents: Pentoxifylline, monoclonal antibodies

Phlebotomy

Surgical intervention and antiobesity drugs

Bariatric surgery

Orlistat

PUFA N-3 polyunsaturated fatty acids; TNF Tumour necrosis factor; URSO Ursodeoxycholic acid