Fig. 3.
Effect of O2·− produced by the mito_4 on the network (30 mitochondria in total) entrainment. A: cytoplasmic O2·− level surrounding (and produced by) the perturbed mitochondrion is high (0.02 mM); as a result, the O2·− arriving the adjacent mitochondria is above the threshold (0.008 mM) to activate their IMACs and entrain the whole network oscillations (B). C: cytoplasmic O2·− level surrounding (and produced by) the mito_4 is relatively low (0.0022 mM), and the O2·− reaching its neighbors is below the threshold level (0.0015 mM); thus it cannot entrain the full depolarization of the network (D).