Fig. 5.

IMAC-mediated ΔΨm oscillations triggering an mPTP-mediated final depolarization wave. A: space-time plot of ΔΨm recorded along the yellow line (left). O₂^·− production rate increased progressively over time, most rapidly in the lower 4 rows of mitochondria {where k_shunt = 0.35[0.3 + 0.7 min (1,e^0.02t/150)]} and more slowly elsewhere {k_shunt = 0.2[0.3 + 0.7 min (1,e^0.02t/150)]}. B: average ΔΨm vs. time. C: mitochondrial O₂^·− (blue) and H₂O₂ (red) concentrations vs. time. k_shunt was initially zero and started to increase at the upward arrows. Black bar below the snapshot indicates the final mPTP-mediated slow wave. Reproduced from (96).