Table 1.

Single-marker association analysis of SNPs rs1051730 and rs481134 with lung cancer

Samples/SNPs	Alleles*	Allele frequency		P†	OR (95% CI)
		Cases	Controls
GELCC (194 familial cases and 217 controls, Caucasians)
rs1051730	G/A	0.4094	0.2938	2.16 × 10−3	1.88 (1.26–2.82)
rs481134	T/C	0.5632	0.5714	0.750	0.94 (0.59–1.29)
MCC (890 sporadic cases and 865 controls, Caucasians)
rs1051730	G/A	0.3975	0.3651	0.040	1.16 (1.01–1.33)
rs481134	T/C	0.5863	0.5891	0.897	0.99 (0.85–1.23)
TXC (1,466 sporadic cases and 1,389 controls, Caucasians)
rs1051730	G/A	0.3767	0.3315	2.79 × 10−4	1.23 (1.10–1.37)
rs481134	T/C	0.5806	0.5621	0.141	1.08 (0.98–1.19)
TXA (268 sporadic cases and 293 controls, African Americans)
rs1051730	G/A	0.1456	0.0911	1.83 × 10−3	1.91 (1.27–2.86)
rs481134	T/C	0.6818	0.7000	0.466	0.90 (0.62–1.18)
Combined (2,818 cases and 2,794 controls)‡
rs1051730	G/A	0.3635	0.3136	1.56 × 10−7	1.24 (1.15–1.35)
rs481134	T/C	0.5909	0.5859	0.514	1.03 (0.95–1.10)

^*Bold letter is the reference allele used for estimating OR.

^†Association was adjusted by sex, age, and smoke using logistic regression model.

^‡Association was adjusted by sex, age, smoke, race, and study sites using logistic regression model.