Table 3.

Subgroup association analysis of SNPs rs481134 and rs1051730 with lung cancer

Samples/SNP	Alleles*	Frequency		P†	Marginal OR (95% CI)
		Cases	Controls
Subjects with genotypes GG at SNP rs1051730
GELCC (64 familial cases and 102 controls)
rs481134	T/C	0.2937	0.4059	0.196	0.68 (0.38–1.22)
MCC (322 sporadic cases and 342 controls)
rs481134	T/C	0.3224	0.3666	0.095	0.82 (0.66–1.03)
TXC (570 sporadic cases and 604 controls)
rs481134	T/C	0.3224	0.3558	0.098	0.86 (0.72–1.03)
TXA (188 sporadic cases and 240 controls)
rs481134	T/C	0.6183	0.6778	0.036	0.72 (0.52–0.98)
Combined (1,144 cases and 1,288 controls)
rs481134	T/C	0.3694	0.4227	7.01 × 10−4	0.81 (0.72–0.92)
Subjects with genotypes CC at SNP rs481134
GELCC (62 familial cases and 69 controls)
rs1051730	G/A	0.7411	0.4851	4.51 × 10−4	4.47 (3.64–5.31)
MCC (299 sporadic cases and 297 controls)
rs1051730	G/A	0.6829	0.5997	1.82 × 10−3	1.46 (1.22–1.70)
TXC (488 sporadic cases and 422 controls)
rs1051730	G/A	0.6695	0.5781	7.21 × 10−5	1.49 (1.29–1.68)
TXA (120 sporadic cases and 138 controls)
rs1051730	G/A	0.2288	0.1168	2.20 × 10−4	2.83 (1.63–4.91)
Combined (969 cases and 926 controls)
rs1051730	G/A	0.6232	0.5093	4.42 × 10−11	1.60 (1.46–1.74)

^*Bold letter is the reference allele used for estimating OR.

^†Association was adjusted by the same covariates as the single-locus analysis.