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. Author manuscript; available in PMC: 2013 May 1.
Published in final edited form as: Wiley Interdiscip Rev Dev Biol. 2012 Jan 27;1(3):315–327. doi: 10.1002/wdev.30

Figure 1. Developmental progression of myogenesis and myogenic gene expression.

Figure 1

Top panel: presomitic mesoderm cells express Pax3 (pale blue) and low levels of Myf5 (pale yellow) transcripts. Epithelial somite stage is omitted. Second panel: appearance of sclerotome, dermomyotome (Pax3+), and primary (1°) myogenic cells (Myf5+) at the dorsal medial edge. Pax3 expression is at a higher level at the lateral edge. Third panel: Pax7 expression emerges and overlaps with Pax3+ cells in the central dermomyotome in more mature somites. Bottom panel: Vertical division of the central dermomyotomal cells, which give rise to the secondary (2°) myogenic progenitors. These cells are presumed to give rise to more progenitors and Myf5+ or MyoD+ myogenic cells. The lateral Pax3+ cells give rise to migrating myoblasts entering the ventral body wall and limbs. Keys to cells with specific gene expression are at the bottom.