Table 1.
Mean arterial pressure, glomerular filtration rate, total renal blood flow, filtration fraction, urine flow, and hematocrit in normoglycemic control and hyperglycemic diabetic rats during baseline and after acute NADPH-oxidase inhibition by apocynin
| MAP, mmHg | GFR, ml•min−1•kidney−1 | RBF, ml•min−1•kidney−1 | FF | VU, μl•min−1•kidney−1 | Hct, % | |
|---|---|---|---|---|---|---|
| Normoglycemic (n = 11) | ||||||
| Baseline | 107 ± 4 | 1.4 ± 0.1 | 8.8 ± 1.0 | 0.31 ± 0.03 | 3.4 ± 0.5 | 46 ± 0.4 |
| Apocynin | 103 ± 4 | 1.2 ± 0.1 | 9.0 ± 1.0 | 0.27 ± 0.02 | 3.5 ± 0.4 | 46 ± 0.5 |
| Diabetic (n = 13) | ||||||
| Baseline | 104 ± 2 | 2.2 ± 0.3* | 10.1 ± 0.9 | 0.45 ± 0.04* | 24.9 ± 3.5* | 48 ± 0.4* |
| Apocynin | 105 ± 3 | 2.4 ± 0.2* | 11.1 ± 1.3 | 0.42 ± 0.03* | 20.8 ± 3.2* | 49 ± 0.7* |
Values are means ± SE; n is the number of rats. MAP, mean arterial pressure; GFR, glomerular filtration rate; RBF, total renal blood flow; FF, filtration fraction; VU, urine flow; Hct, hematocrit.
*
P < 0.05 compared with corresponding control.