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. 2012 Apr 4;302(11):R1313–R1326. doi: 10.1152/ajpregu.00086.2012

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Copyright © 2012 the American Physiological Society

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Fig. 1. — Leptin receptor-dependent lesion of arcuate nucleus (Arc) neurons by unilateral leptin conjugated to saporin (Lep-SAP) injection. A: representative immunohistochemical (IHC) images of alpha-melanocyte stimulating hormone (α-MSH) and agouti gene-related peptide (AGRP) neurons after unilateral injection of Lep-SAP into the Arc in Sprague-Dawley (S/D) or Zucker fa/fa (Zucker) rats. Calibration bar = 100 μm. Numbers of α-MSH-positive (B) and AGRP-positive (C) cell bodies in the Arc of S/D or Zucker fa/fa rats (n = 3 or 4 rats per group) after unilateral injection of Lep-SAP or control blank saporin (B-SAP). Quantified data are shown for four hypothalamic levels, each indicated in millimeters caudal to bregma. *P < 0.001 vs. the noninjected (contralateral) side.