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. 2012 Mar 28;107(12):3479–3492. doi: 10.1152/jn.00789.2011

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Fig. 5. — Depolymerization of actin enhances synaptic responses to high frequency stimulation. A: at low frequencies of stimulation (1/15 Hz), latrunculin-A had no effect on excitatory postsynaptic current (EPSC) amplitude. Ai: means of representative traces of EPSCs before and after latrunculin-A treatment. Aii: mean normalized amplitudes of EPSCs during control, latrunculin-A treatment, and 30 min after latrunculin-A (6 preparations). B: periods of high-frequency stimulation (5 Hz) reduced the mean EPSC amplitude. Bi: representative traces (10 sequential EPSCs) before and during 5-Hz stimulation. Bii: means of these EPSCs before, during, and after 5-Hz stimulation. Biii: mean normalized amplitudes of EPSCs during 1/15 Hz stimulation, at 5 Hz, and returned to 1/15 Hz in controls (6 preparations). C: after latrunculin-A treatment 5-Hz stimulation had less effect. Ci: representative traces (10 sequential EPSCs) before, during, and after 5-Hz stimulation in latrunculin-A-treated preparations. Cii: means of these EPSCs before, during, and after 5-Hz stimulation. Ciii: mean normalized amplitudes of EPSCs during 1/15 Hz stimulation, at 5 Hz, and returned to 1/15 Hz in latrunculin-A-treated preparations (6 preparations).