Table 1.
Characteristics of study subjects and their association with resistance to isoniazid, rifampicin and ethambutol based on GenoType® MTBDRplus and GenoType® MTBDRsl assays
| Characteristics | Number of patients | Anti-TB drug resistance | |||||||
|---|---|---|---|---|---|---|---|---|---|
| INH N (%) |
P-value | RMP N (%) |
P-value | MDR N (%) |
P-value | EMB N (%) |
P-value | ||
| Gender | |||||||||
| Male | 153 | 19 (12.4) | 0.556 | 9 (5.9) | 0.925 | 7 (4.6) | 0.707 | 5 (3.3) | 0.831 |
| Female | 107 | 16 (15.0) | 6 (5.6) | 6(5.6) | 3 (2.8) | ||||
| Age (years) | |||||||||
| < 40 | 214 | 29 (13.6) | 0.927 | 11 (5.1) | 0.348 | 9 (4.2) | 0.205 | 7 (3.3) | 0.696 |
| ≥ 40 | 46 | 6 (13.0) | 4 (8.7) | 4 (8.7) | 1 (2.2) | ||||
| TB history | |||||||||
| New | 214 | 22 (10.3) | 0.001 | 8 (3.7) | 0.002 | 8(3.7) | 0.044 | 6 (2.8) | 0.582 |
| Previously treated | 46 | 13 (28.3) | 7 (15.2) | 5 (10.9) | 2 (4.3) | ||||
| HIV status | |||||||||
| Negative | 194 | 29 (14.9) | 0.228 | 9 (4.6) | 0.180 | 9 (4.6) | 0.647 | 7 (3.6) | 0.395 |
| Positive | 66 | 6 (9.1) | 7 (10.6) | 4 (6.1) | 1 (1.5) | ||||
| Total | 260 | 35 (13.5) | 15 (5.8) | 13 (5.0) | 8 (3.1) | ||||
N number, INH isoniazid, RMP rifampicin, MDR multidrug resistance, EMB ethambutol