Table 2.
Frequency of gene mutations associated with resistance to isoniazid and rifampicin by GenoType® MTBDRplus, and to ethambutol by GenoType® MTBDRsl assays
| Anti TB-drugs | Number of resistant isolates | Patterns of gene mutations (wild-type/mutant) | Amino acid Changes |
Frequency (n) |
|---|---|---|---|---|
| Isoniazid | 35 | katGWT/katGMUT1 | Ser315Thr1 | 33 |
| inhA WT1/inhA MUT1 | C15T | 2 | ||
| Rifampicin | 15 | rpoB WT8/rpoB MUT3 | Ser531Leu | 11 |
| rpoB WT7/rpoB MUT2B | His526Asp | 1 | ||
| rpoB WT2 &3/NA | Unknown | 1 | ||
| rpoB WT4/ND | Unknown | 1 | ||
| rpoB WT6/NA | Unknown | 1 | ||
| Ethambutol | 8 | embB WT/embB MUT1A | Met306Ile | 2 |
| embB WT/embB MUT1B | Met306Val | 1 | ||
| embB WT/ND | Unknown | 5 | ||
n number of isolates, WT wild-type, MUT mutant, ND no mutation detected at mutant probe, NA mutant probe is not available