Table 5.

List of pancreas tissue-specific proteins which have not been previously studied as serum cancer or benign disease biomarkers

Gene	Protein name	Proteome identified in:
		CM proteome from pancreatic cancer cell lines [33]	Pancreatic cancer ascites proteome [32]	Pancreatic juice proteome [33]	Pancreatic tissuea		Non-pancreas proteome
					Normal	Cancer
AQP8	Aquaporin 8
CTRB1	Chymotrypsinogen B1		√				√ Down Syndrome amniotic fluid [22]
CTRB2	Chymotrypsinogen B2			√	√
CTRC	Chymotrypsin C (caldecrin)			√	√	√
CUZD1	CUB and zona pellucida-like domains 1			√	√
KLK1	Kallikrein 1			√	√	√
PNLIPRP1	Pancreatic lipase-related protein 1			√	√
PNLIPRP2	Pancreatic lipase-related protein 2			√	√		√ CM proteome from Hep 3B [52]
PRSS3	Protease, serine, 3		√	√	√	√	√ HCC-38b; HCC-1143b; normal amniotic fluid [23]
REG1B	Regenerating islet-derived 1 beta			√	√	√
REG3G	Regenerating islet-derived 3 gamma			√			√ Seminal plasma proteome [25]
SLC30A8	Solute carrier family 30 (zinc transporter), member 8

^aProteome of normal and cancer pancreatic tissue (H Kosanam et al., unpublished work); ^bCM proteome of breast cancer cell lines (M Pavlou et al., unpublished work). CM: conditioned media.