Table 1.

Genes associated with psoriasis susceptibility¹

Gene* (location)	Protein function	Pathway	References
IL23R (1p31)	IL-23 receptor subunit	IL-23 signalling	(Capon et al., 2008; Cargill et al., 2007; Ellinghaus et al., 2010; Nair et al., 2009; Strange et al., 2010)
IL28RA (1p36)	IL-29 receptor subunit.	IFN signalling	(Strange et al., 2010)
LCE3B/3C/3D (1q21)	Keratinocyte structural protein	Skin barrier function	(de Cid et al., 2009; Ellinghaus et al., 2010; Zhang et al., 2009)
REL (2p16)	NF-κB subunit	NF-κB signalling	(Strange et al., 2010)
IFIH1/ MDA5 (2q24)	Innate antiviral receptor	IFN signalling	(Strange et al., 2010)
ERAP1 (5q15)	Amino peptidase processing MHC class I ligands	Antigen presentation	(Strange et al., 2010; Sun et al., 2010a)
IL4,IL13 (5q31)	Th2 cytokines	IL-4/IL-13 signalling	(Nair et al., 2009)
IL12B (5q33)	Subunit shared by the IL-12 and IL-23 cytokines	IL-23 signalling	(Cargill et al., 2007; Ellinghaus et al., 2010; Nair et al., 2009; Zhang et al., 2009) (Huffmeier et al.,2010)**
TNIP1 (5q33)	Inhibitor of TNF- induced NF-κB activation	NF-κB signalling	(Nair et al., 2009; Strange et al., 2010; Sun et al., 2010a)
PTTG1 (5q33)	Anaphase promoting complex substrate	Cell cycle control/DNA repair	(Sun et al., 2010a)
HLA-C (6p21)	MHC class I antigen	Antigen presentation	(Capon et al., 2008; Ellinghaus et al., 2010; Nair et al., 2009; Strange et al., 2010; Zhang et al., 2009)
TRAF3IP2 (6q21)	Adaptor mediating IL-17 induced NF-kB activation	IL-17/NF-□B signalling	(Ellinghaus et al., 2010; Strange et al., 2010) (Huffmeier et al., 2010)**
TNFAIP3 (6q23)	Inhibitor of TNF- induced NF-κB activation	NF-κB signalling	(Nair et al., 2009; Strange et al., 2010)
CSMD1 (8p23)	Tumour suppressor gene	Unknown	(Sun et al., 2010a)
IL23A (12q13)	IL-23 subunit	IL-23 signalling	(Nair et al., 2009; Strange et al., 2010)
GJB2 (13q11)	Gap junction protein	Electrolyte transport	(Sun et al., 2010a)
NFKBIA (14q13)	Inhibitor of NF-κB activation	NF-κB signalling	(Strange et al., 2010; Stuart et al., 2010)
FBXL19 (16p11)	Putative inhibitor of NF-κB activation	NF-κB signalling	(Stuart et al., 2010)
NOS2 (17q11)	Induced nitric oxide synthase	Innate antibacterial response	(Stuart et al., 2010)
SERPINB8 (18q21)	Serine protease inhibitor	Unknown	(Sun et al., 2010a)
TYK2 (19p13)	Tyrosine kinase associated with cytokine receptors	IL-23 and IFN signalling	(Strange et al., 2010)
ZNF816A (19q13)	Zinc Finger Protein	Unknown	(Sun et al., 2010a)
ZNF313/RNF114 (20q13)	E3 ubiquitin ligase	IFN signalling	(Capon et al., 2008; Nair et al., 2009; Strange et al., 2010; Stuart et al., 2010)

¹All the loci included in the Table showed genome-wide significant association (P < 5 × 10⁻⁸) with psoriasis, in at least one GWAS.

^*Gene of interest found in the disease-associated susceptibility interval;

^**Psoriatic arthritis GWAS.