Table 2.

Pleiotropic disease susceptibility genes associated with psoriasis

Gene	Other Associated Diseases	References
IL23R	Crohn’s disease Ankylosing spondylitis	(Burton et al., 2007; Duerr et al., 2006)
REL	Rheumatoid arthritis Celiac disease Crohn’s disease	(Franke et al., 2010; Gregersen et al., 2009; Trynka et al., 2009)
IFIH1	Type I diabetes	(Nejentsev et al., 2009; Smyth et al., 2006)
ERAP1	Ankylosing spondylitis	(Burton et al., 2007)
CDKAL1	Crohn’s disease Type 2 diabetes	(Barrett et al., 2008; Quaranta et al., 2009; Zeggini et al., 2007)
IL12B	Crohn’s disease Ulcerative colitis	(Fisher et al., 2008; Parkes et al., 2007)
PTTG1	Systemic lupus erythematosus	(Han et al., 2009)
TNIP1	Systemic lupus erythematosus	(Gateva et al., 2009)
TNFAIP3	Rheumatoid arthritis Systemic lupus erythematosus Celiac disease	(Graham et al., 2008; Musone et al., 2008; Plenge et al., 2007; Thomson et al., 2007; Trynka et al., 2009)
TYK2	Type I diabetes Multiple sclerosis Systemic lupus erythematosus Crohn’s disease	(Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene), 2009; Franke et al., 2010; Sigurdsson et al., 2005; Wallace et al., 2010)