. Author manuscript; available in PMC: 2013 Feb 1.

Published in final edited form as: Int J Obes (Lond). 2011 Nov 29;36(8):1040–1046. doi: 10.1038/ijo.2011.226

TABLE 2.

Food intake following central administration of leptin

Time (h) from i3v leptin	% Reduction in food intake
	Control	Postnatal low protein
0–2	27.5 ± 3.9	24.1 ± 7.9
0–4	16.6 ± 6.0	25.7 ± 11.5
0–24	12.7 ± 2.0	24.2 ± 10.9
0–48	16.3 ± 1.9	36.11 ± 11.0^*

Three-month-old rats received saline or 5 μg recombinant leptin i3v. Data are expressed as the percentage reduction in food intake for each animal given leptin compared to when it was given saline (n= 9–13).

P = 0.035 for effect of leptin in PLP compared to control rats by Mann-Whitney U-test (n = 9–13). The reductions in food intake elicited by leptin were all significant (P < 0.05).