. Author manuscript; available in PMC: 2012 Aug 15.

Published in final edited form as: Clin Cancer Res. 2011 Nov 23;18(4):1015–1027. doi: 10.1158/1078-0432.CCR-11-2189

Table 1. Known Genetic Aberrations in Cell Lines Used in this Study.

	22RV1	DU145	PC3	HCT116	H1299
p53 Genotype	WT	MT	Null	WT	Null
IR-induced p21^WAF1	Yes	No	No	Yes	No
IR-Induced G1/S Checkpoint	Minimal	No	No	Intact	No
PTEN	WT	Heterozygous	Null	WT	WT
Known DNA Repair Gene Defects	MMR (MSH2)	MMR (MLH1, PMS2, MSH2)	None	MMR (MLH1)
Other reported mutations (COSMIC^[1])	PIK3CA	CDKN2A, RB1, STK11,		PIK3CA, CDKN2A, CTNNB1, KRAS,	NRAS

^[1]