Skip to main content
. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Gene Ther. 2011 Dec 15;20(1):7–15. doi: 10.1038/gt.2011.205

Figure 6.

Figure 6

Priming an adaptive T cell immune response. CTL were primed from PBMC cocultured with autologous DC that had been loaded with either Mel888 (control) or Mel888 treated with Mv at an MOI of 0.1 (0.1). A; Degranulation of CTL following coculture with either Mel888, SkOV or an equal volume of media free of target cells. B; Intracellular IFNγ within CTL primed from PBMC following coculture with Mel888, SkOV or media control. C; Cr-51 release from Mel888 following coculture with CTL; no significant release of Cr51 was detected from irrelevant SkOV targets. Data shown are from one donor, representative of experiments in 12 donors, in 9 of which a specific anti-melanoma response was elicited.