Table 2. Ultrasequencing values for integrins and extracellular matrix-related genes.

Gene family	Gene name	Ensembl number	Fold change
			50 µg/mL Doxyc.	200 µg/mL Doxyc.	500 µg/mL Doxyc.
Integrins	CTGF	ENSG00000118523	−2.04	−2.70	−4.55
	CRELD1	ENSG00000163703	2.60	3.40	3.47
	CYR61	ENSG00000142871	−1.82	−1.92	−2,33
	ICAM1	ENSG00000090339	2.13	3.40	3.89
	ITGA4	ENSG00000115232	−1.33	−2.04	−1.64
	ITGA5	ENSG00000161638	1.87	2.26	2.31
	ITGB1	ENSG00000150093	−1.16	−1.69	−1.35
	ITGB8	ENSG00000105855	−1.54	−2.50	−1.89
	ITGBL1	ENSG00000198542	−1.43	−1.72	−2.13
Integrin-interacting proteins	SLC3A2	ENSG00000168003	2.75	3.22	3.15
	THBS1	ENSG00000137801	−1.39	−1.67	−1.85
	SVEP1	ENSG00000165124	−1.44	−1.71	−2.06
Collagens	COL12A1	ENSG00000111799	−1.32	−1.92	−1.82
	COL5A2	ENSG00000204262	−1.25	−1.47	−1.61
Extracellular matrix	LAMB1	ENSG00000091136	−1.52	−2.04	−2.33
	LAMA3	ENSG00000053747	−1.47	−1.41	−1.32
	LAMA4	ENSG00000112769	−1.33	−1.82	−1.79
	SPARC	ENSG00000113140	−1.09	−1.18	−1.37

Values are represented as the mean fold change of 10 patients with respect to untreated controls.