Table 3. Subgroup analyses for dominant model, recessive model and the allele contrast I versus D.

	Intervention group (n)	Dominant model			Recessive model			The allele contrast I versus D
		I2	RE pooled ORs (95% CI)	P	I2	RE pooled ORs(95% CI)	P	I2	RE pooled OR (95% CI)	P
Mean age
≤60 y, low median	5	0%	0.87 (0.64, 1.18)	<0.05	1%	1.12 (0.88, 1.42)	<0.05	0%	1.01 (0.85, 1.20)	0.0001
>60 y, high median	4	0%	2.71 (1.60, 4.61)		0%	2.39 (1.67, 3.43)		0%	2.07 (1.61, 2.68)
Category of ACEIs
enalapril (or major)	4	42%	1.04 (0.52, 2.09)	0.4307	44%	1.52 (0.77, 3.01)	0.6334	70%	1.30 (0.73, 2.35)	0.7469
others	7	63%	1.23 (0.73, 2.09)		58%	1.65 (1.14, 2.40)		67%	1.36 (1.02, 1.81)
Interval of treatment
>2 months	4	0%	0.96 (0.67, 1.37)	0.1155	7%	1.09 (0.81, 1.47)	0.0016	0%	0.95 (0.79, 1.14)	0.0023
≤2months	5	67%	1.56 (0.75, 3.24)		0%	2.03 (1.47, 2.80)		50%	1.57 (1.15, 2.13)
Proportion of male
<60%, low median	4	72%	1.59 (0.67, 3.80)	0.2530	0%	1.85 (1.29, 2.66)	0.2895	78%	1.39 (0.90, 2.17)	1.0000
>60%, high median	3	67%	0.87 (0.28, 2.69)		67%	1.46 (0.75, 2.83)		40%	1.39 (0.91, 2.13)
Population
Asian	7	65%	1.49 (0.78, 1.74)	0.0012	65%	1.82 (1.20, 2.74)	0.0298	73%	1.55 (1.11, 2.16)	0.0042
Caucasian	4	0%	0.85 (0.58, 1.25)		0%	1.23 (0.77, 1.98)		5%	0.99 (0.76, 1.31)