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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Adv Drug Deliv Rev. 2011 May 3;64(1):29–39. doi: 10.1016/j.addr.2011.04.006

Fig.2.

Fig.2

Determinants of interstitial transport of nanoparticulate carriers (NP) in tumors. (1) Absence of lymphatics reduces the clearance of interstitial fluid and soluble proteins, resulting in high interstitial fluid pressure (IFP), thus reducing the pressure gradient between microvascular pressure (MVP) and IFP and the associated convective transport. (2) Physical barriers due to presence of extracellular matrix proteins (Pr) or high cell density reduce diffusive and convective transport. (3) NP binding to proteins and cell membrane reduces the free concentration available for transport.