Figure 4.

IL-10^−/− mice have enhanced levels of proinflammatory mediators in the serum, following Mtb infection as compared with WT mice. WT BALB/c (open bars) and IL-10^−/− (closed bars) BALB/c mice were infected with Mtb. At specific time points, postexposure groups of mice were killed, serum was obtained from the coagulated blood samples and screened by a multiplex cytokine profiler assay (Supporting Information Table 2). The data are mean±SEM and are representative of two independent experiments (n=3–5 mice per group). ^*p<0.05; ^**p<0.01 (unpaired Student's t-test).