Table 1.
AChE activity (% inhibition) in the rat after dermal exposure to carbofuran (6 h)a
| Dose (mg kg−1 day−1) | Male RBC | Male brain | Female RBC | Female brain | Combined sexes RBC | Combine sexes brain |
|---|---|---|---|---|---|---|
| 0 | 3303 ± 817 | 47 768 ± 2227 | 3148 ± 553 | 46 768 ± 2756 | 3226 ± 683 | 47 268 ± 2492 |
| 25 | 2389 ± 454* | 37 826 ± 4444** | 2599 ± 646 | 37 553 ± 3278** | 2494 ± 554 ** | 37 689 ± 3803** |
| (27.7%) | (20.8%) | (17.5%) | (19.7%) | (22.7%) | (20.3%) | |
| 75 | 2410 ± 912* | 32 391 ± 7908** | 2517 ± 818 | 36 702 ± 4761** | 2464 ± 845** | 34 547 ± 6727** |
| (27.0%) | (32.2%) | (20.0%) | (21.5%) | (23.6%) | (26.9%) | |
| 150 | 2133 ± 959** | 30 199 ± 9543** | 2630 ± 724 | 32 271 ± 6733** | 2382 ± 866** | 31 235 ± 8108** |
| (35.4%) | (36.8%) | (16.5%) | (31.0%) | (26.2%) | (33.9%) | |
| 250 | 2059 ± 516** | 28 523 ± 6685** | 2379 ± 762 | 31 354 ± 7738** | 2219 ± 654** | 29 939 ± 7186** |
| (37.7%) | (40.3%) | (24.4%) | (33.0%) | (31.2%) | (36.7%) |
*
P < 0.05 different from control.
**
P < 0.01 different from control.
a
Mean enzyme activity U/L ± standard deviation (percentage inhibition compared with control).2