Table 2.
AChE activity (% inhibition) in the rat after dermal exposure (0–6 h) with carbofuran at 75 mg kg−1a
| Exposure duration (h) | Male RBC | Male brain | Female RBC | Female brain | Combined sexes RBC | Combined sexes brain |
|---|---|---|---|---|---|---|
| 0 | 4314 ± 883 | 49 148 ± 1698 | 4285 ± 748 | 48 930 ± 2215 | 4300 ± 797 | 49 039 ± 1924 |
| 0.5 | 3253 ± 656* | 33 983 ± 5890* | 3304 ± 752* | 32 731 ± 6569* | 3279 ± 687** | 33 357 ± 6106** |
| (24.6%) | (30.9%) | (22.9%) | (33.1%) | (23.7%) | (32.0%) | |
| 1.5 | 2811 ± 718* | 29 817 ± 5613* | 3035 ± 692* | 31 178 ± 7357* | 2923 ± 696** | 30 498 ± 6407** |
| (34.8%) | (39.3%) | (29.2%) | (36.3%) | (32.0%) | (37.8%) | |
| 3.0 | 2948 ± 797* | 32 236 ± 6557* | 2808 ± 603* | 31 149 ± 6289* | 2878 ± 692** | 31 693 ± 6278** |
| (31.7%) | (34.4%) | (34.5%) | (36.3%) | (33.1%) | (35.4%) | |
| 6.0 | 2418 ± 771* | 26 094 ± 8434* | 2579 ± 1120* | 28 846 ± 5513* | 2499 ± 940** | 27 470 ± 7077** |
| (44.0%) | (46.9%) | (39.8%) | (41.0%) | (41.9%) | (44.0%) | |
| 6.0 + 18 h recovery | 3134 ± 973* | 30 172 ± 5369* | 2893 ± 861* | 32 047 ± 6191* | 3014 ± 898** | 31 110 ± 5721** |
| (27.4%) | (38.6%) | (32.5%) | (34.5%) | (30.1%) | (36.6%) |
*
P < 0.05 different from control.
**
P < 0.01 different from control.
a
Mean enzyme activity U/L ± standard deviation (percentage inhibition compared with control).3