Table 3.
AChE activity (% inhibition) in the rat after dermal exposure to carbofuran (21 days)a
| Dose (mg kg−1 day−1) | Male RBC | Male brain | Female RBC | Female brain | Combined sexes RBC | Combined sexes brain |
|---|---|---|---|---|---|---|
| 0 | 2977 ± 665 | 50 957 ± 2010 | 2758 ± 780 | 50 495 ± 1686 | 2868 ± 714 | 50 726 ± 1821 |
| 20 | 2045 ± 352** | 42 666 ± 4179** | 2351 ± 1145 | 40 546 ± 3179** | 2198 ± 857** | 41 606 ± 3742** |
| (31.3%) | (16.3%) | (14.8%) | (19.7%) | (23.1%) | (18.1%) | |
| 50 | 1561 ± 352** | 33 580 ± 4867** | 1216 ± 324** | 29 652 ± 3662** | 1389 ± 374** | 31 616 ± 4676** |
| (47.6%) | (34.1%) | (55.9%) | (41.3%) | (51.6%) | (37.5%) | |
| 100 | 1242 ± 326** | 26 266 ± 3089** | 832 ± 330** | 24 346 ± 5711** | 1037 ± 382** | 25 306 ± 4499** |
| (58.3%) | (48.5%) | (69.8%) | (51.8%) | (63.5%) | (50.0%) |
* P < 0.05 different from control.
**
P < 0.01 different from control.
a
Mean enzyme activity U/L ± standard deviation (percentage inhibition compared with control).6