Table 4.
Dermal absorption of carbofuran in human and rat skin exposed to Furadan® 5G
| Species/dose level | Human/9.56 ± 0.48 mg cm−2 | Rat/10.40 ± 0.34 mg cm−2 |
|---|---|---|
| Skin excess (µg cm−2) | 576.89 ± 35.54 | 590.73 ± 32.08 |
| % applied dose | 97.80 ± 1.38 | 92.07 ± 3.03 |
| Stratum corneum (SC) (µg cm−2) | < LOQ | < LOQ |
| % applied dose | < LOQ | < LOQ |
| Epidermis + dermis (ED) (µg cm−2) | 0.03 ± 0.03 | 1.30 ± 1.18 |
| % applied dose | 0.005 ± 0.005 | 0.20 ± 0.18 |
| Receptor fluid (RF) (µg cm−2) | 1.163 ± 0.117 | 0.682 ± 0.453 |
| % applied dose | 0.03 ± 0.02 | 0.106 ± 0.067 |
| Dermal delivery (ED + RF) (µg cm−2) | 0.193 ± 0.143 | 1.983 ± 1.616 |
| % applied dose | 0.03 ± 0.02 | 0.31 ± 0.24 |
| Total recovery (% applied dose) | 97.83 ± 1.40 | 92.43 ± 2.97 |