Table 4.
Tertile 1 (< 4) | Tertile 2 (4–20) | Tertile 3 (> 20) | P (trend) | |
---|---|---|---|---|
| ||||
N | 24 | 24 | 24 | |
Age | 58 ± 14 | 68 ± 9 | 66 ± 12 | 0.02 |
Female (%) | 25 | 29 | 58 | 0.02 |
Black (%) | 4 | 8 | 25 | 0.03 |
Creatinine Clearance (ml/min) | 57 ± 22 | 47 ± 16 | 45 ± 18 | 0.03 |
Blood Pressure (mm Hg) | ||||
Systolic | 129 ± 21 | 142 ± 18 | 148 ± 19 | 0.001 |
Diastolic | 73 ± 10 | 76 ± 12 | 77 ± 9 | 0.29 |
Co-morbidities (%) | ||||
Hypertension | 91 | 88 | 92 | 0.92 |
Diabetes | 17 | 42 | 29 | 0.39 |
Prior cardiovascular disease | 8 | 54 | 29 | 0.12 |
Medications (%) | ||||
ACE inhibitors | 57 | 38 | 42 | 0.32 |
ARB | 43 | 38 | 38 | 0.72 |
β-blockers | 43 | 54 | 63 | 0.19 |
Serum Laboratory Data | ||||
Calcium (mg/dl) | 9.7 ± 0.5 | 9.6 ± 0.4 | 9.5 ± 0.5 | 0.19 |
Phosphate (mg/dl) | 2.9 ± 0.6 | 3.2 ± 0.6 | 3.0 ± 0.6 | 0.96 |
25-hydroxyvitamin D (ng/ml) | 31 ± 11 | 31 ± 13 | 31 ± 15 | 0.94 |
1,25-dihydroxyvitamin D (pg/ml) | 33 ± 14 | 31 ± 12 | 41 ± 15 | 0.05 |
Parathyroid hormone (pg/ml) | 42 (23, 67) | 52 (29, 128) | 69 (39, 89) | 0.12 |
Fibroblast growth factor 23 (RU/ml) | 74 (35, 121) | 110 (65, 159) | 93 (52, 114) | 0.23 |
Urine Laboratory Data | ||||
Urinary phosphate excretion (mg/d) | 851 ± 373 | 661 ± 222 | 551 ± 191 | <0.001 |
Urinary calcium excretion (mg/d) | 87 ± 77 | 54 ± 42 | 64 ± 77 | 0.25 |