Table 1.

Annual rates of change of lumbar spine (LS) bone mineral density (BMD) in relation to the date of the final menstrual period (FMP) and the influence of body mass index (BMI), race and age at the FMP on LS BMD before, during and after the FMP ^a

	Annual BMD slopes during each time interval before and after the FMP (95% Confidence Interval)			Cumulative BMD change b(95% Confidence Interval)
	Pre-Transmenopause 5 to 1 yr before FMP	Transmenopause 1 yr before to 2 yr after FMP	Postmenopause 2 yr to 5 yr after FMP
Caucasian referent c	−0.02% (−0.08%, +0.05%)	−2.46% (−2.61%, −2.31%)	−1.06% (−1.21%, −0.91%)	−10.6% (−11.2%, −10.0%)
Baseline BMI (per kg/m2) d	+0.008% (+0.001%, +0.015%)	+0.063% (+0.046, +0.080%)	+0.018% (+0.001%, +0.035%)	+0.28% (+0.21%, +0.34%)
Race:  Japanese	+0.01% (−0.12%, +0.14%)	+0.20% (−0.12%, +0.52%)	−0.04% (−0.35%, +0.28%)	+0.5% (−0.7%, +1.8%)
Chinese	−0.14% (−0.27%, −0.01%)	−0.23% (−0.54%, +0.08%)	−0.22% (−0.51%, +0.06%)	−2.0% (−3.1%, −0.7%)
African American	−0.07% (−0.18%, +0.04%)	+0.27% (+0.02%. +0.52%)	+0.13% (−0.11%, +0.37%)	+0.9% (−0.1%, +1.9%)
Increasing age at FMP (yr)	+0.002% (−0.020%, +0.016%)	−0.050% (−0.091%, −0.009%)	+0.040% (+0.002%, +0.079%)	−0.04% (−0.19%, +0.12%)

^aIn addition to variables listed in table, model is also adjusted for baseline BMD and clinical site. Slope referent values are for Caucasian women of average age at FMP (51.7 years), average baseline BMD (1.066 gms/cm2 at the lumbar spine), and average BMI at baseline (27.1 kg/m²).

^bCumulative change during 10-year period, spanning 5 years before and 5 years after the final menstrual period.

^cStatistically significant associations are shown in bold italic typeface; significance test of non-zero slopes for Caucasian referent; significance test of difference between slopes in Caucasian referent and slopes in the other specified groups.

^dSlopes for BMI, race and age at FMP, when added to the Caucasian slope referent values, give the slope in women who have each of these characteristics.