TABLE 2.
Histological changes in IgAN vs. controls
| IgAN (n = 40) | Control (n = 4) | P value | ||
|---|---|---|---|---|
| Proximal tubular AGT | 0.40 ± 4.24 | 0.08 ± 5.02 | 0.04 | |
|
| ||||
| Glomerular lesionsa | ||||
| Glomerular obsolescence | 0.1 ± 0.1 | 0.1 ± 0.1 | 0.6 | |
| Glomerular sclerosis | 0.6 ± 0.6 | 0.0 ± 0.0 | 0.02 | |
| Mesangial proliferation | 0.4 ± 0.5 | 0.0 ± 0.0 | 0.01 | |
| Mesangial matrix increase | 0.4 ± 0.5 | 0.0 ± 0.0 | 0.005 | |
|
| ||||
| Tubulo-interstitial and vascular lesions | ||||
| Interstitial fibrosis | No. of patients (%) | |||
| 0 (absent) | 24 (60.0) | 3 (75.0) | 0.7 | |
| 1 (≤25%) | 10 (25) | 1 (25.0)b | ||
| 2 (26–50%) | 6 (15) | 0 | ||
| 3 (>50%) | 0 | 0 | ||
| Tubular atrophy | No. of patients (%) | |||
| 0 (absent) | 31 (77.5) | 3 (75.0) | 0.8 | |
| 1 (≤25%) | 6 (15.0) | 1 (25.0)b | ||
| 2 (26–50%) | 3 (7.5) | 0 | ||
| 3 (>50%) | 0 | 0 | ||
| Arteriolar hyalinosis | No. of patients (%) | |||
| 0 (absent) | 36 (90.0) | 4 (100) | 0.5 | |
| 1 (mild) | 4 (10.0) | 0 | ||
| 2 (severe, any) | 0 | 0 | ||
| 3 (severe, many) | 0 | 0 | ||
| Arterial intimal thickening | No. of patients (%) | |||
| 0 (absent) | 33 (82.5) | 4 (100) | 0.4 | |
| 1 (≤25%) | 7 (17.5) | 0 | ||
| 2 (26–50%) | 0 | 0 | ||
| 3 (>50%) | 0 | 0 | ||
Values are means ± SD. AGT, angiotensinogen (arbitrary unit); IgAN, IgA nephropathy.
a
Glomeruli were scored individually and the mean scores calculated for all nonsclerosed glomeruli semiquantitatively.
b
Less than 10% was involved. An adequate specimen for the light microscopy containing sufficient cortical area was considered as a biopsy with at least 10 glomeruli. Consequently, a total of 1290 and 70 glomeruli in the specimens from IgAN and control individuals, respectively, were observed.