Table 3.
Pooled incidences of complications and functional outcome following an IPAA procedures in studies published since 2000 compared to studies published before 2000
| Since 2000 | Before 2000 | P value | |||||
|---|---|---|---|---|---|---|---|
| Number of studies | Number of patients | Pooled incidences | Number of studies | No. of patients | Pooled incidences | ||
| Complications | % (95% CI) | % (95%CI) | |||||
| Pouch failure | 43 | 13,249 | 4.3 (3.5–5.3) | 39 | 8,877 | 6.8 (5.8–8.4) | 0.0038 |
| Pouch failure: FU > 5 years | 22 | 9,873 | 4.7 (3.4–6.4) | 11 | 3,198 | 8.5 (5.4–13.2) | |
| Pelvic sepsis | 46 | 13,450 | 7.5 (6.1–9.1) | 41 | 9,082 | 9.5 (8.2–10.9) | NS |
| Fistula | 38 | 12,398 | 4.5 (3.5–5.7) | 30 | 5,120 | 5.5 (4.3–7.0) | NS |
| Stricture | 35 | 12,219 | 10.7 (8.2–13.8) | 28 | 5,185 | 9.2 (6.8–12.4) | NS |
| Pouchitis | 39 | 12,685 | 26.8 (21.0–33.5) | 33 | 7,289 | 18.8 (15.7–22.4) | NS |
| Sexual dysfunction | 13 | 6,131 | 3.0 (1.7–5.2) | 21 | 5,112 | 3.6 (2.7–4.7) | NS |
| Small bowel obstruction | 34 | 11,895 | 11.4 (9.1–14.1) | 27 | 5,853 | 13.1 (11.0–15.7) | NS |
| Fecal incontinence | %(95%CI) | % (95%CI) | |||||
| Mild day incontinence | 21 | 6,988 | 14.3 (7.3–25.9) | 31 | 4,313 | 17.0 (12.8–22.2) | NS |
| Severe day incontinence | 13 | 3,718 | 6.1 (2.9–12.3) | 27 | 3,914 | 3.7 (2.8–4.8) | NS |
| Mild night incontinence | 9 | 5,423 | 17.3 (4.7–46.8) | 17 | 2,582 | 13.1 (9.5–17.9) | NS |
| Severe night incontinence | 10 | 3,614 | 7.6 (2.5–21.3) | 9 | 1,271 | 4.5 (3.0–6.7) | NS |
| Frequency | Mean (95%CI) | Mean (95%CI) | |||||
| Frequency day | 26 | 5,321 | 5.7 (4.9–6.7) | 13 | 2,277 | 5.2 (4.0–6.7) | NS |
| Frequency night | 22 | 7,117 | 1.5 (1.0–2.1) | 20 | 2,950 | 1.0 (0.6–1.6) | NS |
| Frequency 24 h | 26 | 5,132 | 5.9 (5.0–6.9) | 20 | 3,547 | 5.2 (4.4–6.1) | NS |
CI confidence interval, FU follow-up period