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. 2012 Jun;180(6):2321–2329. doi: 10.1016/j.ajpath.2012.02.011

Figure 2.

Figure 2

Fibrin(ogen) does not contribute to acute APAP-induced liver injury. A–C: Fasted wild-type mice were treated with ancrod (1.5 U) or vehicle (300 μL sterile PBS) at 2 hours before treatment with APAP (300 mg/kg); samples were collected at 24 hours and serum ALT activity (A) was determined. D–F: Fasted Fbg+⧸− control mice and Fbg−⧸− were treated with APAP (300 mg/kg); samples were collected at 24 hours. Serum ALT activity was determined (D). B, C, E, and F: Representative photomicrographs of fibrin (dark) staining in livers after APAP treatment. Data are expressed as means + SEM. n = 7 to 12 mice per group. Original magnification, ×100.