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. 2012 Jun;180(6):2321–2329. doi: 10.1016/j.ajpath.2012.02.011

Figure 5.

Figure 5

Inhibition of plasminogen activation and complete plasminogen deficiency reduces APAP-induced liver injury. A–D: Fasted wild-type mice were treated with APAP (300 mg/kg) or saline vehicle. Two hours later, mice were treated with tranexamic acid (TA; 600 mg/kg i.p.) or saline vehicle. Serum ALT activity (A) was determined at 6 and 24 hours after APAP treatment; area of necrosis (B) was determined 24 hours after APAP treatment. C and D: Representative photomicrographs of H&E-stained liver sections at 24 hours from mice treated with APAP and then treated with saline vehicle or tranexamic acid (TA). E–H: Fasted wild-type (Plg+⧸+) or plasminogen-deficient (Plg−⧸−) mice were treated with APAP (300 mg/kg) or saline vehicle; samples were collected at 24 hours. Serum ALT activity (E) and area of necrosis (F) were determined. G and H: Representative photomicrographs of H&E-stained liver sections from APAP-treated Plg+⧸+ or Plg−⧸− mice at 24 hours after APAP treatment. Data are expressed as means + SEM. *P < 0.05 versus APAP-treated mice given saline vehicle (A and B) or versus APAP-treated Plg+⧸+ mice (E and F). n = 3 to 10 mice per group. Original magnification, ×100.