Figure 2.

Ki-67 immunostaining on uterine sections of intact Pten^+/+ mice (A), Pten^+/+ mice that had undergone oophorectomy (Ovx) (B), intact Pten^+/− mice (C), and Pten^+/− mice that undergone oophorectomy (D). Original magnification, ×40. (E) Quantitation of Ki-67-positive cells. Oophorectomy reduced Ki-67-positive cells in the normal epithelium of Pten^+/+ mice. Statistical analysis was performed with the unpaired t-test. *P values ranging between 0.01 and 0.05 were considered significant; ***P values < 0.001 were considered highly significant.