Table 3.

Endometrial Lesions in Estradiol-Treated Pten Heterozygous Mice That Had Undergone Oophorectomy

Genotype	Treatment (weeks)	n	No. (%) of mice with disease	No. (%) of mice with CAH	Mice with invasion	No. of CAH per mouse (mean ± SD)	Size (mm2) of CAH (mean ± SD)	Range of size (mm2)
Pten+/−(E)	24	5	5/5 (100)	5	3	19.8 ± 3.86‡	0.20 ± 0.17	0.04–1.2
Pten+/−(P)	24	5	5/5 (100)	5	0	24.4 ± 9.29‡	0.14 ± 0.11	0.04–0.8
Wild type (E)	24	5⁎	0	0	0
Pten+/−(E)	12	7	7/7 (100)†	6	0	6.86 ± 4.30§	0.11 ± 0.09	0.04–0.25
Pten+/−(P)	12	7	7/7 (100)	7	0	8.4 ± 5.27§	0.12 ± 0.09	0.04–0.4
Wild type (E)	12	6⁎	0	0	0

E, estradiol pellets; P, placebo pellets.

^⁎Mice had dilated complex hyperplasia without atypia.

^†One mouse showed hyperplasia without atypia.

^‡P > 0.05, difference was not statistically significant.

^§P > 0.05, difference was not statistically significant. These numbers were not compared with those in ‡.