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. 2012 Feb 9;40(10):e72. doi: 10.1093/nar/gks001

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — Aggregation of single location estimates. (A–C) Estimates based on the fragment GC curve (black) trace similar paths as loess (cyan) estimated on observed counts (blue) on multiple scales. (D–F) Estimates based on alternative models compared with observed counts on 1 kb bins. (D) Read model, predictions based on GC of the 5′ read only (W_0,75); (E) Two-ended model uses GC (30 bp) from both ends of the fragments; (F) Fragmentation model based on location-specific composition around the 5′-end. See Supplementary methods for details on how models for (E) and (F) were defined and estimated.