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CN gain from tumor sample. Counts and corrected counts at position 29 000 kb on chromosome 2. (A) Unnormalized counts at 1 kb bins (top), corrected by loess (center) and corrected by fragment model (bottom). GC curves estimated on chromosome 1 (which has no large CN changes). (B) Histogram of normalized counts at 28–30 mb (underlined on left plots).
