Figure 6.

Proposed model for OxyR-mediated oxidative stress responses in P. aeruginosa. In contact with H₂O₂, bacterial cells respond rapidly to the stress and alter the gene expression patterns to prevent the damages caused by H₂O₂. OxyR plays central roles in these processes by activating both core and variable regulons to detoxify and eliminate the toxic effect of H₂O₂. The activity of OxyR itself is controlled through reduction of the newly identified thioredoxin system TrxA/TrxB2. Green arrow means an activation effect; red arrow means an inhibition effect.