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. 2012 Jan 28;40(10):4358–4367. doi: 10.1093/nar/gks037

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Model showing Fis-mediated silencing of mom. The rightmost gene in the Mu genome is mom. P_mom, the regulatory region of mom has been enlarged. The −35 and −10 promoter elements of P_mom are boxed. The dashed arrows indicate binding of Fis (small oval) to multiple sites in the promoter (as shown by DNase I footprinting). RNAP (large oval) cannot bind to P_mom because Fis is occluding the RNAP binding region. The Fis binding sites implicated in interfering with RNAP binding and thus with transcription are indicated by thickened arrows. Effect of Fis on other regions of the genome (see ‘Discussion’ section) is not shown.