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. 2012 Jan 28;40(10):4553–4561. doi: 10.1093/nar/gks053

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Model for the role of branched DNA in FANCD2 monoubiquitylation. According to the crystal structure of the ID complex (22), the monoubiquitylation site (K563) of FANCD2 is located near the interface with FANCI. Therefore, UBE2T and FANCL may not allow access to the FANCD2 monoubiquitylation site in the ID complex (left panel). Branched DNA may bind to FANCI, as revealed by the crystal structure of the FANCI–DNA complex (22), and thus induce a conformational change of the ID complex to expose the FANCD2 monoubiquitylation site for UBE2T and FANCL (right panel).