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. 2012 Feb 8;40(10):4574–4588. doi: 10.1093/nar/gks057

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — Model of dependence of Brx1 on Ebp2 for assembly into pre-ribosomes. Ebp2 (E) and Brx1 (B) are represented with yellow and green, respectively. X (red) and Y (blue) represent other proteins present in pre-ribosomes. Each X and each Y can represent one or more proteins. Black lines mark interactions. Loss of interaction is shown as dashed line. Arrows point FROM the protein required to recruit another protein into pre-ribosomes TO the protein dependent on the first protein to be in pre-ribosomes. (A) In the wild-type, Ebp2 and Brx1 interact with each other and each interacts with other proteins within pre-ribosomes (pre-60S). (B) Loss of interaction between Ebp2 and Brx1 does not cause either protein to be absent from pre-ribosomal particles, presumably due their interactions with other proteins. (C) In the absence of Brx1, Ebp2 is still present in pre-ribosomes. (D) The absence of Ebp2 affects one or more proteins that stabilize the association of Brx1 with pre-ribosomes. In their absence, Brx1 is absent from pre-ribosomes.