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. 2012 Feb 7;40(10):4711–4722. doi: 10.1093/nar/gks065

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Template-directed ligation increases average length and compositional diversity in silico. (a) Length distribution of binary sequences with or without template-directed ligation [r_lig = 0 (red) or 10⁶ (blue); r_con = 10 in both cases]. Length is the number of bases per molecule. (b) Compositional diversity C₃ at several r_con values, with or without template-directed ligation, when monomer reactivity is biased [19-fold difference between k_con; r_lig = 0 (red) or 10⁶ (blue); length = 15].