Table 1.
Maternal characteristics of women exposed to an SSRI and unexposed
| Characteristic | Exposed to SSRIs |
Unexposed (n=843 797) |
|||
| First trimester (n=4183) | Paused during pregnancy (n=806) |
||||
| n (%) | n (%) | p Value* | n (%) | p Value* | |
| Education | <0.01 | <0.001 | |||
| Short | 1731 (41.38) | 372 (46.15) | 280 447 (33.24) | ||
| Medium | 1119 (26.75) | 225 (27.92) | 254 194 (30.13) | ||
| Long | 1262 (30.17) | 193 (23.95) | 272 380 (32.28) | ||
| Missing values | 71 (1.70) | 16 (1.99) | 36 776 (4.36) | ||
| Annual household income | 0.12 | <0.001 | |||
| <$58 335 | 1320 (31.56) | 264 (32.75) | 210 290 (24.92) | ||
| $58 335–$93 656 | 1101 (26.32) | 222 (27.54) | 212 110 (25.14) | ||
| $93 656–$119 082 | 906 (21.66) | 185 (22.95) | 211 436 (25.06) | ||
| $119 082 or greater | 856 (20.46) | 135 (16.75) | 207 247 (24.56) | ||
| Missing values | 0 (−) | 0 (−) | 2714 (0.32) | ||
| Age (years) | <0.001 | <0.001 | |||
| <20 | 70 (1.67) | 20 (2.48) | 23 324 (2.76) | ||
| 21–25 | 555 (13.27) | 122 (15.14) | 129 059 (15.30) | ||
| 26–30 | 1364 (32.61) | 269 (33.37) | 318 664 (37.77) | ||
| 31–35 | 1423 (34.02) | 295 (36.60) | 268 959 (31.87) | ||
| >35 | 771 (18.43) | 100 (12.41) | 102 791 (12.18) | ||
| Missing values | 0 (−) | 0 (−) | 0 (−) | ||
| Parity | <0.001 | <0.001 | |||
| 1 | 1983 (47.41) | 282 (34.99) | 368 168 (43.63) | ||
| 2 | 1320 (31.56) | 310 (38.46) | 308 992 (36.62) | ||
| >2 | 833 (19.91) | 208 (25.81) | 162 030 (19.20) | ||
| Missing values | 47 (1.12) | 6 (0.74) | 4607 (0.55) | ||
| Daily cigarettes | 0.53 | <0.001 | |||
| 0 | 2810 (67.18) | 532 (66) | 660 888 (78.32) | ||
| 1–10 | 1049 (25.08) | 211 (26.18) | 128 269 (15.2) | ||
| 11–20 | 66 (1.58) | 11 (1.36) | 5294 (0.63) | ||
| >20 | 138 (3.30) | 34 (4.22) | 20 967 (2.48) | ||
| No information | 118 (2.82) | 18 (2.23) | 27 580 (3.27) | ||
| Missing values | 2 (0.05) | 0 (−) | 799 (0.09) | ||
| Pre-pregnancy BMI | 0.89 | <0.001 | |||
| <21 | 391 (12.23) | 66 (12.60) | 53 500 (13.95) | ||
| 21–25 | 1393 (43.59) | 233 (44.47) | 186 428 (48.62) | ||
| 26–30 | 705 (22.06) | 117 (22.33) | 74 673 (19.48) | ||
| >30 | 493 (15.43) | 74 (14.12) | 41 652 (10.86) | ||
| Missing values | 214 (6.70) | 35 (6.68) | 27 161 (7.08) | ||
Information on pre-pregnancy BMI was only available for women giving birth after 1 January 2004. Thus, this cohort comprises 387 142 pregnancies.
*
χ2 tests were used to assess the overall p value for the group comparison with pregnancies exposed to an SSRI during the first trimester.
BMI, body mass index; SSRI, selective serotonin reuptake inhibitor.