Table 2.
Association of OBSCN Variants with Aspirin Exacerbated Respiratory Disease
| |
|
|
MAF |
Co-dominant |
Dominant |
Recessive |
||||
|---|---|---|---|---|---|---|---|---|---|---|
| SNP (AA change) | Position | HWE | AERD (n=163) | ATA (n=429) | OR (95% CI) | p-Value | OR (95% CI) | p-Value | OR (95% CI) | p-Value |
| rs10157526A>G | Intron 8 | 0.541 | 0.150 | 0.167 | 0.87 (0.61–1.26) | 0.47 | 0.82 (0.54–1.23) | 0.33 | 1.29 (0.40–4.12) | 0.67 |
| rs10916282C>A | Intron 8 | 0.571 | 0.147 | 0.167 | 0.85 (0.59–1.23) | 0.39 | 0.79 (0.52–1.19) | 0.26 | 1.29 (0.40–4.12) | 0.67 |
| rs12063816A>G | Intron 8 | 0.551 | 0.095 | 0.098 | 0.98 (0.62–1.53) | 0.91 | 0.99 (0.61–1.59) | 0.95 | 0.75 (0.08–7.42) | 0.80 |
| rs1757157T>C | Intron 8 | 0.170 | 0.279 | 0.291 | 0.92 (0.68–1.23) | 0.57 | 0.93 (0.64–1.35) | 0.70 | 0.79 (0.38–1.65) | 0.53 |
| rs17640616G>C | Intron 8 | 0.299 | 0.052 | 0.066 | 0.71 (0.40–1.28) | 0.26 | 0.72 (0.40–1.30) | 0.28 | . | . |
| rs1757149T>C | Intron 9 | 0.591 | 0.334 | 0.364 | 0.86 (0.65–1.13) | 0.27 | 0.76 (0.52–1.10) | 0.14 | 0.98 (0.56–1.72) | 0.95 |
| rs1629294T>G | Intron 9 | 0.548 | 0.365 | 0.380 | 0.93 (0.71–1.22) | 0.58 | 0.79 (0.54–1.15) | 0.21 | 1.20 (0.71–2.02) | 0.50 |
| rs1771462C>G | Intron 9 | 0.583 | 0.337 | 0.366 | 0.88 (0.67–1.15) | 0.35 | 0.71 (0.49–1.03) | 0.07 | 1.24 (0.72–2.13) | 0.44 |
| rs2776856T>C | Intron 9 | 0.673 | 0.350 | 0.383 | 0.87 (0.66–1.14) | 0.30 | 0.66 (0.46–0.96) | 0.03 | 1.30 (0.78–2.18) | 0.32 |
| rs2776855A>C | Intron 9 | 0.331 | 0.160 | 0.181 | 0.84 (0.59–1.20) | 0.34 | 0.80 (0.53–1.20) | 0.28 | 0.98 (0.33–2.96) | 0.98 |
| rs10916287C>T | Intron 9 | 0.706 | 0.160 | 0.184 | 0.84 (0.59–1.19) | 0.33 | 0.81 (0.54–1.21) | 0.30 | 0.88 (0.30–2.61) | 0.82 |
| rs11586055C>G | Intron 9 | 0.474 | 0.107 | 0.114 | 0.94 (0.62–1.42) | 0.78 | 0.91 (0.58–1.45) | 0.70 | 1.18 (0.28–4.92) | 0.82 |
| rs1771459G>A | Intron 9 | 0.730 | 0.334 | 0.357 | 0.90 (0.68–1.18) | 0.44 | 0.73 (0.50–1.05) | 0.09 | 1.30 (0.76–2.25) | 0.34 |
| rs1757133C>T | Intron 9 | 0.331 | 0.160 | 0.181 | 0.84 (0.59–1.20) | 0.34 | 0.80 (0.53–1.20) | 0.28 | 0.98 (0.33–2.96) | 0.98 |
| rs6701173G>A | Intron 9 | 0.038a | 0.224 | 0.237 | 0.98 (0.71–1.35) | 0.89 | 0.92 (0.63–1.33) | 0.64 | 1.42 (0.59–3.45) | 0.44 |
| rs3856331G>A | Intron 9 | 0.038a | 0.224 | 0.237 | 0.98 (0.71–1.35) | 0.89 | 0.92 (0.63–1.33) | 0.64 | 1.42 (0.59–3.45) | 0.44 |
| rs12077365T>C | Intron 11 | 0.706 | 0.160 | 0.184 | 0.84 (0.59–1.19) | 0.33 | 0.81 (0.54–1.21) | 0.30 | 0.88 (0.30–2.61) | 0.82 |
| rs1888680A>T | Intron 12 | 0.420 | 0.439 | 0.396 | 1.16 (0.88–1.51) | 0.29 | 1.06 (0.72–1.57) | 0.77 | 1.48 (0.92–2.38) | 0.11 |
| rs6426493G>A | Intron 12 | 0.512 | 0.442 | 0.407 | 1.13 (0.86–1.47) | 0.39 | 1.01 (0.68–1.49) | 0.97 | 1.45 (0.90–2.32) | 0.12 |
| rs1411912C>A | Intron 13 | 0.382 | 0.439 | 0.397 | 1.15 (0.88–1.51) | 0.30 | 1.05 (0.71–1.56) | 0.80 | 1.48 (0.92–2.38) | 0.11 |
| rs10158275G>T | Intron 14 | 0.004a | 0.399 | 0.412 | 0.98 (0.74–1.30) | 0.89 | 1.13 (0.76–1.68) | 0.56 | 0.74 (0.43–1.30) | 0.30 |
| rs4653544G>A | Intron 14 | 0.753 | 0.304 | 0.304 | 0.98 (0.74–1.30) | 0.87 | 0.92 (0.64–1.34) | 0.68 | 1.12 (0.60–2.09) | 0.72 |
| rs287606G>A | Intron 15 | 0.055 | 0.212 | 0.217 | 1.02 (0.73–1.42) | 0.91 | 0.95 (0.65–1.39) | 0.81 | 1.65 (0.63–4.29) | 0.31 |
| rs397637G>T | Intron 16 | 0.035a | 0.212 | 0.216 | 1.03 (0.74–1.44) | 0.86 | 0.95 (0.65–1.39) | 0.81 | 1.85 (0.70–4.90) | 0.21 |
| rs391597A>T | Intron 16 | 0.035a | 0.212 | 0.216 | 1.03 (0.74–1.44) | 0.86 | 0.95 (0.65–1.39) | 0.81 | 1.85 (0.70–4.90) | 0.21 |
| rs1108210A>C | Intron 16 | 0.728 | 0.160 | 0.188 | 0.82 (0.58–1.16) | 0.25 | 0.79 (0.53–1.18) | 0.24 | 0.81 (0.28–2.35) | 0.69 |
| rs878388G>A | Intron 16 | 0.242 | 0.442 | 0.389 | 1.22 (0.93–1.60) | 0.15 | 1.16 (0.78–1.72) | 0.46 | 1.54 (0.95–2.51) | 0.08 |
| rs549590T>C | Intron 17 | 0.028a | 0.212 | 0.218 | 1.01 (0.73–1.41) | 0.94 | 0.93 (0.64–1.36) | 0.72 | 1.85 (0.70–4.90) | 0.21 |
| rs424645C>T | Intron 17 | 0.014a | 0.215 | 0.224 | 1.00 (0.72–1.39) | 0.99 | 0.92 (0.63–1.34) | 0.65 | 1.85 (0.70–4.90) | 0.21 |
| rs1188722C>T (L2116F) | Exon 23 | 0.597 | 0.291 | 0.242 | 1.26 (0.94–1.68) | 0.12 | 1.10 (0.76–1.60) | 0.62 | 2.52 (1.30–4.87) | 0.006 |
| rs867599C>A | Intron 25 | 0.991 | 0.258 | 0.225 | 1.15 (0.85–1.56) | 0.36 | 1.07 (0.74–1.56) | 0.71 | 1.78 (0.86–3.70) | 0.12 |
| rs3795782T>C | Intron 27 | 0.496 | 0.178 | 0.198 | 0.88 (0.62–1.24) | 0.46 | 0.86 (0.58–1.27) | 0.45 | 0.86 (0.30–2.50) | 0.79 |
| rs11581037C>G | Intron 28 | 0.309 | 0.098 | 0.108 | 0.89 (0.58–1.37) | 0.59 | 0.89 (0.55–1.42) | 0.62 | 0.78 (0.15–4.00) | 0.76 |
| rs12061320G>A (V2648V) | Exon 31 | 0.828 | 0.316 | 0.330 | 0.91 (0.69–1.21) | 0.52 | 0.75 (0.51–1.08) | 0.12 | 1.38 (0.78–2.44) | 0.27 |
| rs3795785C>T (R2812W) | Exon 32 | 0.687 | 0.288 | 0.282 | 1.01 (0.76–1.36) | 0.93 | 0.89 (0.61–1.28) | 0.52 | 1.60 (0.83–3.08) | 0.16 |
| rs1150906G>T | Intron 33 | 0.068 | 0.215 | 0.230 | 0.97 (0.70–1.34) | 0.84 | 0.91 (0.62–1.33) | 0.62 | 1.39 (0.55–3.51) | 0.49 |
| rs3795790A>T (S3373C) | Exon 39 | 0.811 | 0.317 | 0.331 | 0.91 (0.69–1.21) | 0.53 | 0.74 (0.51–1.08) | 0.12 | 1.39 (0.79–2.46) | 0.25 |
| rs4653938C>G | Intron 39 | 0.541 | 0.503 | 0.472 | 1.15 (0.89–1.49) | 0.29 | 0.88 (0.58–1.32) | 0.53 | 1.68 (1.11–2.54) | 0.02 |
| rs1150909C>T | Intron 43 | 0.636 | 0.288 | 0.244 | 1.22 (0.91–1.63) | 0.18 | 1.04 (0.72–1.51) | 0.83 | 2.52 (1.30–4.88) | 0.006 |
| rs1150910C>T | Intron 44 | 0.032a | 0.215 | 0.226 | 0.99 (0.71–1.38) | 0.95 | 0.92 (0.63–1.34) | 0.66 | 1.62 (0.63–4.18) | 0.32 |
| rs207951A>T | Intron 50 | 0.596 | 0.291 | 0.246 | 1.22 (0.91–1.63) | 0.18 | 1.06 (0.73–1.54) | 0.77 | 2.41 (1.25–4.63) | 0.008 |
| rs2087121G>A | Intron 50 | 0.393 | 0.506 | 0.472 | 1.16 (0.90–1.50) | 0.26 | 0.89 (0.59–1.33) | 0.56 | 1.70 (1.12–2.57) | 0.01 |
| rs1188729G>C (C4642S) | Exon 54 | 0.665 | 0.288 | 0.245 | 1.21 (0.91–1.62) | 0.19 | 1.04 (0.71–1.50) | 0.86 | 2.53 (1.31–4.89) | 0.006 |
| rs6700528G>A | Intron 57 | 0.831 | 0.433 | 0.446 | 0.92 (0.71–1.20) | 0.54 | 0.78 (0.53–1.15) | 0.21 | 1.09 (0.69–1.73) | 0.70 |
| rs369909G>C (L5269V) | Exon 59 | 0.089 | 0.206 | 0.221 | 0.97 (0.69–1.36) | 0.87 | 0.90 (0.61–1.32) | 0.57 | 1.64 (0.64–4.23) | 0.31 |
| rs1188710C>G (E5891Q) | Exon 73 | 0.077 | 0.442 | 0.418 | 1.07 (0.82–1.40) | 0.63 | 1.01 (0.68–1.50) | 0.96 | 1.23 (0.76–1.99) | 0.41 |
| rs369252C>A | Intron 76 | 0.596 | 0.291 | 0.245 | 1.24 (0.93–1.65) | 0.15 | 1.04 (0.72–1.51) | 0.84 | 2.71 (1.41–5.21) | 0.003 |
| rs12096217G>A | Intron 76 | 0.625 | 0.095 | 0.104 | 0.89 (0.58–1.37) | 0.59 | 0.88 (0.55–1.42) | 0.61 | 0.77 (0.15–3.94) | 0.75 |
| rs729258C>T | Intron 77 | 0.073 | 0.227 | 0.244 | 0.97 (0.70–1.34) | 0.86 | 0.93 (0.64–1.35) | 0.70 | 1.25 (0.50–3.10) | 0.64 |
| rs3795811C>T | Intron 78 | 0.745 | 0.304 | 0.316 | 0.91 (0.68–1.20) | 0.49 | 0.77 (0.53–1.11) | 0.16 | 1.31 (0.72–2.39) | 0.38 |
| rs3795812A>G | Intron 79 | 0.073 | 0.233 | 0.257 | 0.94 (0.68–1.30) | 0.71 | 0.89 (0.61–1.29) | 0.52 | 1.24 (0.53–2.93) | 0.62 |
| rs3795814C>T | Intron 80 | 0.778 | 0.307 | 0.329 | 0.87 (0.66–1.16) | 0.35 | 0.75 (0.52–1.08) | 0.12 | 1.17 (0.64–2.11) | 0.61 |
| rs16848509C>T | Intron 81 | 0.071 | 0.442 | 0.418 | 1.07 (0.81–1.40) | 0.63 | 1.01 (0.68–1.50) | 0.97 | 1.23 (0.76–2.00) | 0.40 |
| rs11582927C>T | Intron 81 | 0.098 | 0.144 | 0.167 | 0.81 (0.56–1.18) | 0.28 | 0.79 (0.52–1.19) | 0.26 | 0.85 (0.21–3.48) | 0.82 |
| rs12061490A>G | Intron 81 | 0.844 | 0.307 | 0.316 | 0.92 (0.69–1.23) | 0.57 | 0.77 (0.53–1.11) | 0.16 | 1.41 (0.78–2.56) | 0.25 |
p-Values are adjusted with initial diagnosed age, sex, smoking, atopy, and body mass index.
Bold values indicate the statistical significance (p<0.05).
a
p-Values of HWE are not significant after correction by number of markers.
SNP, single-nucleotide polymorphism; AA, amino acid; HWE, p-values of deviation from Hardy–Weinberg equilibrium; MAF, minor allele frequency; OR, odds ratio; CI, confidence interval.