Table 4.
Associations Between Polymorphisms of NPPA and Ischemic Stroke with Cardioembolism
| |
|
|
MAF |
p-Value |
|
MAF |
p-Value |
|
||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | SNP | Functional position | CE (n=33) | Control (n=267) | Unadjusted | Adjusteda | Statistical power (%) | CE (n=33) | SVO (n=395) | Unadjusted | Adjusteda | Statistical power (%) |
| NPPB | rs198389A>G | Promoter | 0.156 | 0.125 | 0.488 | 0.822 | 45.46 | 0.156 | 0.133 | 0.596 | 0.444 | 66.11 |
| rs5227G>T | Arg25Leu | 0.000 | 0.000 | — | — | 0.000 | 0.000 | — | — | |||
| rs35640285G>T | Val94Phe | 0.000 | 0.000 | — | — | 0.000 | 0.000 | — | — | |||
| NPPA | rs61757273G>T | Promoter | 0.091 | 0.068 | 0.497 | 0.415 | 30.06 | 0.091 | 0.065 | 0.414 | 0.296 | 40.97 |
| rs198373A>G | Promoter | 0.000 | 0.002 | — | — | 0.000 | 0.010 | — | — | |||
| rs198372G>A | Promoter | 0.000 | 0.002 | — | — | 0.000 | 0.010 | — | — | |||
| rs5063G>A | Val32Met | 0.076 | 0.099 | 0.549 | 0.200 | 30.12 | 0.076 | 0.090 | 0.690 | 0.802 | 45.15 | |
| rs5065T>C | STOP152Arg | 0.030 | 0.006 | 0.039 | 0.002 | 7.29 | 0.030 | 0.004 | 0.023 | 0.020 | 7.32 | |
| rs5067A>G | 3′UTR | 0.030 | 0.006 | 0.039 | 0.002 | 7.29 | 0.030 | 0.004 | 0.023 | 0.020 | 7.32 | |
Bold value indicates the statistical significance of P<0.05.
p-Values of additive model were obtained by logistic analysis.
a
Adjusted for age, sex, and histories of hypertension and diabetes mellitus as covariates.