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Polymerization properties of wild-type and mutated α1-AT. (A) Protein samples (10 μM) were incubated at 42°C for the time spans indicated and then stored on ice until subjected to native PAGE analysis. (B) The rate of polymerization of wild-type (dash-diamond-dash), E342K (dash-box-dash), E342Q (dash-circle-dash), and E342R (dash-down arrow-dash) -mutated α1-AT was determined as a function of monomer loss using the equation for exponential decay (lines).
