Fig. 8.

Platelet depletion in vivo decreases acid-induced lung endothelial TF, vWf, and P-selectin expressions. vWf, von Willebrand factor; TF, tissue factor. Mice were injected intravenously with nonimmune control serum or antiplatelet serum. After 2 h, they were subjected to intranasal saline or acid instillation. Pulmonary vascular cells were freshly isolated 2 h after instillation. Dot plots from single experiments show expression (% of total). The x and y ordinates (gray lines) indicate nonimmune isotype specific IgG label. A: TF and vWf. B: group data, n = 4 mice each bar. Means ± SE, *P < 0.05 compared with saline. C: vWf and P-selectin. D: group data, n = 3 mice each bar. Means ± SE, *P < 0.05 compared with saline.