Table 1.
BALF Th2 cytokines and chemokines in CRA-challenged mice with and without treatment with IC87114
| Cytokine | Control (n = 6 mice) | CRA (n = 12 mice) | CRA + IC87114 (n = 14 mice) |
|---|---|---|---|
| IL-4 | 1.97 ± 0.06 | 7.09 ± 2.97 | 2.8 ± 0.48 |
| IL-5 | 3.83 ± 0.16 | 21.73 ± 8.55* | 6.68 ± 0.74 |
| IL-13 | 0.31 ± 0.04 | 2.49 ± 0.94 | 0.89 ± 0.15 |
| Eotaxin-1 | 31.23 ± 5.96 | 44.64 ± 5.23 | 45.13 ± 5.41 |
| MCP-1 | 13.87 ± 2.97 | 18.91 ± 2.54 | 16.46 ± 2.0 |
| RANTES | 35.62 ± 5.18 | 61.62 ± 13.18* | 50.83 ± 5.55 |
Values are means ± SE, pg/ml.
*
P < 0.05 for comparison of control vs. cockroach antigen (CRA)-challenged group. BALF, bronchoalveolar lavage fluid; MCP, monocyte chemoattractant protein; RANTES, regulated on activation, T cells expressed and secreted.