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Emphysematous changes in the lungs of apolipoprotein E-deficient (Apoe−/−) mice subjected to a Western-type diet for 10 wk. Hematoxylin and eosin-stained lung sections. A: Apoe+/+ mouse fed a chow diet for 10 wk. B: Apoe+/+ mouse fed a Western-type diet (WTD) for 10 wk. C: Apoe−/− mouse fed a chow diet. D: Apoe−/− mouse fed a WTD. E: low-density lipoprotein receptor-deficient (Ldlr−/−) mouse fed a chow diet. F: Ldlr−/− mouse fed a WTD.
